Pages: 1-4

Abstract

Hypercholesterolemia is a condition characterized by high levels of cholesterol in the blood. ‎Vanilla is one among plants that has cholesterol-lowering substances, but research on this ‎subject is still lacking. This study aimed to determine whether ethanol fruit extract vanilla ‎‎(Vanilla planifolia Andrews) can be used as anti-hypercholesterolemia in mice induced by ‎quail egg suspension. Male mice (n=20) were divided into five groups. Group-1 (negative ‎control) was given only high-fat quail egg yolks suspension. Group-2 (positive control) was ‎treated with simvastatin at the dose of 10 mg/kg. Whereas group-3, 4 dan 5 were given vanilla ‎extract of 50, 100, dan 200 mg/kg body weight respectively. The results showed that ethanol ‎fruit extract of vanilla at the dose of 200 mg/kg significantly reduced level of blood cholesterol ‎compared with that of negative control. It is worth concluding that vanilla fruit extract potential ‎to be used as anti-hypercholesterolemia‎‎.