specialty journal of medical research and health science
Determination of In- Vitro Release Kinetics of Metformin Hydrochloride from Six Brands of Metformin Hydrochloride Tablets Available in Bangladesh Using Water Media: A UV Spectroscopic Analysis
Tirtha Nandi, Md. Anisur Rahman, Nusrat Jahan, Rafat Shariar Islam, Omer Fayshal Pavel
The purpose of this study was to determine the in vitro release kinetics of different brands of metformin HCl tablets available in the local pharmaceutical market of Bangladesh. For this study, six widely prescribed brands M1, M2, M3, M4, M5 and M6 were chosen. All of these brands were of 500 mg metformin HCl with strip packaging. The dissolution was carried out using USP apparatus-II and the analysis was performed with the UV spectroscopy. To find out the release kinetics K0 (for zero order), K1 (for first order), Kh (for Higuchi model), K and n (for Korsmeyer-Peppas model) and KHC (for Hixon Crowell model) were determined. The R2 value for each kinetics was also determined which indicated the linearity of release kinetics for each brand. The study found no brand to follow the zero order kinetics mostly. Brand M1 mainly followed the first order (R2=0.982) and the Hixon-Crowell model (R2=0.982) whereas M2 followed the Higuchi model (R2=0.979). At the same time brands M3 and M4 were found to follow Korsmeyer-Peppas (R2=0.996 and 0.992 respectively) and Hixon-Crowell model (R2=0.992 and 0.991 respectively). However, brand M5 and M6 followed Hixon-Crowell equation with the R2 value of 0.984 and 0.988 consecutively. So this study assumes that the available metformin HCl tablet brands available in Bangladesh generally follow the Hixon-Crowell release kinetics.