Pages: 34-41

Abstract

Introduction: Some ailments and restrictions in the diet of patients undergoing hemodialysis ‎can lead to undesirable changes in the nutritional status, a decrease in quality of life, and an ‎increase in disease and mortality. The purpose of this study was to evaluate the nutritional ‎status of these patients and its relationship with the level of leptin and adiponectin and CRP in ‎patients under hemodialysis treatment.‎ Materials and Methods: This was a cross-sectional study with the participation of 42 ‎hemodialysis patients who have been undergoing dialysis for at least 6 months. To assess the ‎nutritional status of the patients, the score of malnutrition-inflammation was used. Leptin, ‎adiponectin and serum level were measured by ELISA method. The level of significance was ‎considered as 0/05. To compare the means, the independent t-test and Mann-Whitney test were ‎used for the nonparametric data and also the relationship between variables was investigated by ‎the Pearson correlation test‏.‏ Findings: The results of this study showed that there was a positive correlation between serum ‎leptin level and body mass index in the patients, which was statistically significant (P = 0.036). ‎Serum adiponectin in patients was negatively associated with their body mass index, nutritional ‎status and serum level. There was a positive and significant correlation between the serum level ‎of the patients and BMI, but this variable was not significantly correlated with the nutritional ‎status of the patients. Leptin, adiponectin and serum levels did not correlate with the nutritional ‎status of the patients, and there was no significant difference in patients with an optimal ‎nutritional status and malnutrition. After assessing the nutritional status of patients using the ‎malnutrition-inflammation score, 24 people were in favorable condition (0-7), 18 were in ‎moderate (8-18) and none of the patients were nutritionally under the Undesirable situation ‎‎(score above 18)‎‏.‏ Discussion and Conclusion: The results of this study showed that leptin, adiponectin and serum ‎levels of patients had a reverse relationship with their score of malnutrition-inflammation. This ‎indicated that these variables were good indicators for the nutritional status of patients ‎undergoing hemodialysis‎.