specialty journal of medical research and health science
Studies on the Influence, Reltionship and Alteration in Serum Cadmium Concentrations in Renal Diseased Patients
Sherine Leena, Deborah Gnana Selvam A., A. Joseph Thatheyus
Background and Objective: Chronic renal disease (CRD) is a growing worldwide problem. The worldwide prevalence of CRD is high and the number of patients with end–stage renal disease (ESRD) has dramatically increased in the past few decades. The aim of the present study was to assess the influence, relationship and alteration in serum cadmium concentrations in renal diseased patients. Subjects were selected from Sumathi Hospital, Madurai, Tamil Nadu, India for the study. A sample size of 75 from in and out-patients was selected and serum samples were collected from them after proper consent and subjected to cadmium analysis by Atomic absorption spectrophotometry. Among the age group of 51 to 60 years, 53% of the patients were found to have cadmium influenced renal disease. Cadmium toxicity induced renal disease was observed in men and they constituted 69% of the study population. Among those with cadmium influenced renal disease, 56% were smokers. Among the study group, 45% had diabetic nephropathy while 31% had chronic renal failure. Those with glomerulonephritis and interstitial nephritis were 19% and 5% respectively. Thirty three percent of the patients were found to contain serum cadmium levels between 0.001 – 0.01ppm. The results showed that the influence of cadmium was significant on the majority of the renal diseases. A study focussing on a single renal disease and cadmium levels would shed a clearer light on the relationship between cadmium and its deleterious effect on kidney functions.