Synthesis, spectroscopic characterization and antibacterial activities of mixed ligand metal(II) complexes of 4-amino-6-chloro-2-methylthiopyrimidine and 1,10-phenanthroline.
Aderoju, A. Osowole, Tolulope, I. Oni
ABSTRACT: Mixed ligand complexes of 4-amino-6-chloro-2-methylthiopyrimidine (L) and 1,10-phenanthroline (L1) with Mn(II), Fe(II), Ni(II), Pd(II), Cu(II) and Zn(II) ions were synthesized and characterized by infrared and electronic spectroscopies, room temperature magnetic moments, melting points and conductance measurements.Infrared spectra data confirmed that coordination was via the nitrogen atoms of the pyrimidine and phenanthroline rings respectively. Electronic spectra and room temperature magnetic moment data indicated that Mn(II), Fe(II), Ni(II)and Cu(II) complexes were octahedral and magnetically concentrated, exhibiting anti-ferromagnetism. In contrast, the Pd(II) and Zn(II) complexes assumedsquare planar and tetrahedralgeometries,and were mononuclear and diamagnetic respectively.The conductance measurements in DMSO showed that the Ni(II), Zn(II) and Pd(II) complexes were 1:1/1:2 electrolytes.The in-vitro antibacterial studies of the complexes against Bacillus cereus, Escherichia coli, Proteus mirabilis, Pseudomonas aureginosa, Klebsiella oxytoca and Staphylococus aureusrevealed that the Mn(II) and Cu(II) complexes had broad-spectrum antibacterial activitywith inhibitory zones range of 30.0-37.0 and 10.0-38.0 mm, proving their potentials as promising broad-spectrum antibacterial agents.