%0 Journal Article
%T Anti-hypercholesterolemic Effect of Ethanol Fruit Extract Of ‎Vanilla (Vanilla planifolia Andrews) on Male Mice
%A Rina Maryani
%A Muhammad Kanedi
%A Endang Nurcahyani
%A Endang L.Widiastuti
%J specialty journal of biological sciences
%@ 2412-7396
%D 2019
%V 5
%N 4
%P 1-4
%X Hypercholesterolemia is a condition characterized by high levels of cholesterol in the blood. ‎Vanilla is one among plants that has cholesterol-lowering substances, but research on this ‎subject is still lacking. This study aimed to determine whether ethanol fruit extract vanilla ‎‎(Vanilla planifolia Andrews) can be used as anti-hypercholesterolemia in mice induced by ‎quail egg suspension. Male mice (n=20) were divided into five groups. Group-1 (negative ‎control) was given only high-fat quail egg yolks suspension. Group-2 (positive control) was ‎treated with simvastatin at the dose of 10 mg/kg. Whereas group-3, 4 dan 5 were given vanilla ‎extract of 50, 100, dan 200 mg/kg body weight respectively. The results showed that ethanol ‎fruit extract of vanilla at the dose of 200 mg/kg significantly reduced level of blood cholesterol ‎compared with that of negative control. It is worth concluding that vanilla fruit extract potential ‎to be used as anti-hypercholesterolemia‎‎.
%U https://sciarena.com/article/anti-hypercholesterolemic-effect-of-ethanol-fruit-extract-of-vanilla-vanilla-planifolia-andrews-on-male-mice