Investigating Nutritional Status of Hemodialysis Patients and Its Relationship with Serum Leptin, Adiponectin and CRP in Patients Undergoing Hemodialysis Treatment
Introduction: Some ailments and restrictions in the diet of patients undergoing hemodialysis can lead to undesirable changes in the nutritional status, a decrease in quality of life, and an increase in disease and mortality. The purpose of this study was to evaluate the nutritional status of these patients and its relationship with the level of leptin and adiponectin and CRP in patients under hemodialysis treatment. Materials and Methods: This was a cross-sectional study with the participation of 42 hemodialysis patients who have been undergoing dialysis for at least 6 months. To assess the nutritional status of the patients, the score of malnutrition-inflammation was used. Leptin, adiponectin and serum level were measured by ELISA method. The level of significance was considered as 0/05. To compare the means, the independent t-test and Mann-Whitney test were used for the nonparametric data and also the relationship between variables was investigated by the Pearson correlation test. Findings: The results of this study showed that there was a positive correlation between serum leptin level and body mass index in the patients, which was statistically significant (P = 0.036). Serum adiponectin in patients was negatively associated with their body mass index, nutritional status and serum level. There was a positive and significant correlation between the serum level of the patients and BMI, but this variable was not significantly correlated with the nutritional status of the patients. Leptin, adiponectin and serum levels did not correlate with the nutritional status of the patients, and there was no significant difference in patients with an optimal nutritional status and malnutrition. After assessing the nutritional status of patients using the malnutrition-inflammation score, 24 people were in favorable condition (0-7), 18 were in moderate (8-18) and none of the patients were nutritionally under the Undesirable situation (score above 18). Discussion and Conclusion: The results of this study showed that leptin, adiponectin and serum levels of patients had a reverse relationship with their score of malnutrition-inflammation. This indicated that these variables were good indicators for the nutritional status of patients undergoing hemodialysis.