Review on Different Aspects of the Photodynamic Product Pheophorbide
Kavita Singh, Divya Chaturvedi, Vinay Kumar Singh
Chlorophyll derivatives such as pheophorbide and chlorophyllin is used to photodynamically destroy snails, Fasciola and mosquito larvae. These photodynamic products are formed from natural chlorophyll extracted from spinach and any other greens plants. Chlorophyll is insoluble in water so by using chemical modification it can be transformed into water soluble chlorophyllin. The acidification of this chlorophyllin transformed into pheophorbide. As a result these substances are applied very easily in aquatic medium due to their solubility in water. This method implicates significantly low concentrations of pheophorbide. Upon illumination it starts reacting and leading to apoptosis as well as necrosis of the cells in the intestine resulting in the death of the snails and larvae. In developing counties to control fasciolosis and other water borne diseases the use of photodynamic product is inexpensive and therefore a promising approach. An outline on the basics of the photodynamic reactions and about the results obtained thus far using photodynamic properties of pheophorbide in order to control the vectors of parasitic diseases and parasites.