%0 Journal Article
%T Synthesis, characterization and antibacterial activities of some metal(II) complexes of 4-amino-2,6-dichloropyrimidine.
%A Aderoju A. Osowole
%A Tolulope I. Oni
%J specialty journal of biological sciences
%@ 2412-7396
%D 2015
%V 1
%N 1
%P 13-18
%X ABSTRACT: The metal(II) complexes of 4-amino-2,6-dichloropyrimidine (L) have been synthesized  and characterized by IR and electronic spectroscopies, percentage metal, magnetic moments, conductance and melting point measurement{where M = Mn, Fe, Co, Ni, Cu and Zn}. The ligand coordinates to the metal ions in the ratio 2L: 1M, through the nitrogen atoms of the pyrimidine ring and the amino group.  The electronic spectra and room temperature magnetic  measurements were consistent with the adoption of a 6-coordinate octahedral geometry for Fe(II) and Ni(II) complexes while Mn(II), Cu(II),Co(II) and Zn(II) complexesassume a 4-coordinate square-planar/ tetrahedral geometry.The conductance measurements in DMSO showed that the Fe(II) complex was covalent, the Ni(II) complex wasa 1:1 electrolyte and the remaining metal complexes were 1:2 electrolytes respectively. The in-vitro antibacterial studies revealed that the Co(II) complex had a broad-spectrum antibacterial activity against Bacillus cereus, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus with inhibitory zones range of 11.0-25.0 mm proving its potential usefulness as a broad-spectrum antibacterial agent.
%U https://sciarena.com/article/synthesis-characterization-and-antibacterial-activities-of-some-metalii-complexes-of-4-amino-26-dichloropyrimidine