Synthesis, characterization and biopotency of some mixed ligand metal(ii) complexes of 4-amino-6-hydroxy-2-mercaptopyrimidine and 2,2’-bipyridine.
Aderoju A. Osowole*, Reuben O. Yoade
ABSTRACT: Mn(II), Co((II), Ni(II), Cu(II), Zn(II), and Pd(II) complexes of mixed ligands, 4-amino-6-hydroxy-2-mercaptopyrimidine (L) and 2,2’-bipyridine (L1) were synthesized and characterized by infrared and electronic spectroscopies, room temperature magnetic moment, molar conductance and melting point measurements. The molar conductance measurements in DMSO indicated that that the Pd(II) complex was 1:1 electrolyte, and the Ni(II) and Zn(II) complexes were 1:2 electrolytes. Infrared spectra showed that the ligands coordinated using N4 chromophores. The electronic spectra and room temperature magnetic moments indicated that the Mn(II) and Co(II) complexes were dimeric, and the Cu(II), Zn(II), Ni(II) and Pd(II) complexes were monomeric octahedral /tetrahedral /square-planar. The in-vitro antibacterial activities of these metal complexes against Bacillus cereus, Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Klebsiella oxytoca and Staphylococcus aureus were moderate to very good with inhibitory zones range of 11.0-38.0 mm