Pages: 1-10

Abstract

Isoxazoles possess numerous pharmaceutical, agricultural and industrial properties. They are antivirus, antitumor, blood pressure lowering agents, anti-Parkinson, anti-Alzheimer etc. the present research paper studies three synthetized combinations: one combination from oximes family and two combinations pertaining to isoxazoles. At first, 4-methylbenzaldehyde was transformed to 4-methylbenzaldoxime (combination 1) using hydroxylamine pyridine hydrochloride, as the solvent. Then, the resulting oxime (combination 1) was transformed to nitrile oxide with the increase in sodium hypochlorite at the same time with which process [3+2] cycloaddition was carried out using propargyl alcohol and (3-para-tolyl isoxazole-5-yl)-methanol (combination 2) was prepared. Esterification was the result of the effect of pantothenic acid in dichloromethane solvent on Combination 2 and (3-para-tolyl-isoxazole-5-yl)-methyl pentanoate was produced. The structures of the synthetized combinations were verified using spectroscopy, 1H NMR FT-IR and 13C NMR.