One of the most highly regarded philosophical theories addressed by Mulla Sadra the acceptance of which has a big impact on other philosophical is the motion in the category of substance. Muslim philosophers before Mulla Sadra denied the substantive motion and criticized it. Finally Mulla Sadra paid attention to the substantive motion in his transcendent philosophy such that the belief in this motion played an important role in his philosophy. Mulla Sadra’s look at this discussion is unique and using means of motion, he proves the substantive motion. Substantive motion that forms one of the branches of originality and gradation of existence is the basis for many transcendental philosophy issues. In this study the theory of substantive motion is examined in four directions: a) the background of substantive motion, b) the reasons and proofs mentioned to prove it, c) the analysis of criticisms against this theory d) results that related to the theory.