The issue of "moral responsibility" is one of the most significant moral issues that has caught the attention of moral philosophers. In the course of history of moral discussions, many issues have been debated on the meaning of responsibility, its conditions and properties of the responsible man. The importance of this issue becomes understood when we pay attention to its relationship with some philosophic-theological discussions as well as the data of natural sciences and humanities. This issue from one perspective is intertwined with such issues as causality, determinism and volition. On other hand, it is interrelated with such vital theological issues as omniscience and omnipotence of God and divine providence. The despisers of moral responsibility struggle to prove through different proofs that human actions are contingent upon the conditions and modes that do not need any other reason. Moreover, they seek to demonstrate that human will has no role in their existence or absence. Determinists provide certain reasons in order to prove their claims in this regard. Some of these scholars deny human will and moral responsibility based on the law of causality. Some others have become bogged down in determinism due to their defected understanding of religious doctrines like Absolute Power (omnipotence), omniscience and divine providence. They deny moral responsibility and human actions. Some Asharite thinkers have resorted to the notions of "God's Omnipotence" in order to deny all types of influence and interference of other issues in the accomplishment of human actions.